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. 2020 Feb 28;10:3760. doi: 10.1038/s41598-020-60638-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The expression of PAR bZIP TFs in other models of acquired epilepsy. (a) Hippocampal expression of PAR bZIP transcription factors (Hlf, Dbp, Tef and E4bp4) in four different rat models of status epilepticus: systemic KA (n = 12 in each group) and pilocarpine administration (n = 12 in each group), self-sustained status epilepticus (SSSE, n = 5 in control group, n = 6 in SSSE group) and amygdala kindling (n = 12 in each group)²⁶. All rats involved in the study were male. White and grey boxes represent control and epilepsy model groups, respectively. Differential expression of the genes Hlf, Tef, Dbp and E4bp4 was performed using the Linear models for microarray (Limma) (b) Relative expression of PAR bZIP TFs after intrahippocampal injection of NMDA or bicuculline in adult male mice (n = 5 in each group). The t-test was performed to evaluate significance. *p < 0.05, **p < 0.005, ***p < 0.001. Figures were created using R version 3.4.3., https://www.R-project.org and GraphPad Prism version 8.3.1 for macOS, www.graphpad.com.