Fig. 2. Lamprey elicit a distinct VLRB response from that of a mouse model when challenged with the same immunogen.

Mouse serum prior to the immunization (t = 0 wk) was collected and analyzed on the CFG array (a, b). Lamprey and mice were immunized with type AB human erythrocytes and inactivated SIV particles three times at 2-week intervals. Serum was isolated from both lamprey and mice 2 weeks after the final immunization (t = 8 wk), and screened on the CFG glycan microarray. The binding profile on the CFG are shown for mouse IgM (c, d 1:50 dilution), and lamprey VLRB (e, f 1:10 dilution). The network of common and unique binders is represented by a force graph (g) and the Pearson r correlation analysis between lamprey VLRB and mouse IgM binding profiles for each sample (h).