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. 2020 Feb 28;10:3669. doi: 10.1038/s41598-020-60314-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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At each stage of the IA continuum. (a) Prevalence of participants (%) stratified as having a high-risk of progression to the next stage/outcome using naive T-cells. HC healthy control (n = 120); at-risk cohort (n = 158); EAC early arthritis clinic (n = 294); MTX tx: methotrexate treated early RA (n = 120); Rem: RA in remission group (n = 145). (b) Prevalence of participants (%) categorised as high-risk using naïve T-cells, who actually progressed to the next stage/outcome. At-risk -> IA: at-risk individual progressing to IA; ev IA −>RA: evolving IA patients progressing to RA; RA- > non-resp: RA patients treated with MTX, not achieving response; Rem->flare: RA patients achieving remission on sc-DMARD and flaring during follow-up.