Table 1.
Summary of the potential druggable targets that might be suitable for pharmacological modulation of selected behavioral and psychological symptoms of dementia (BPSD): psychosis, aggression, and agitation
| Matching with BPSD pathology | Indicated by experimental studies | ||
|---|---|---|---|
| Target | Pharmacological activity | Target | Pharmacological activity |
| Serotonin 5-HT2A receptors | Antipsychotic, antiaggressive | Muscarinic M1/M2 receptors | Antipsychotic, procognitive |
| Serotonin 5-HT1A receptors | Antiaggressive | Cannabinoid receptor CB1 | Antiaggressive |
| Serotonin transporter | Antiaggressive | Metabotrophic glutamate 2 receptor (mGlu2) | Antipsychotic |
| Dopamine D1, D2 receptors | Antipsychotic, antiaggressive | Serotonin 5-HT6 receptors | Procognitive, anxiolytic |
| Alpha-1 adrenoreceptor | Antiaggressive | ||