Table 2.
Relative proportions of post-index study outcomes, visits, and costs by hypoglycemia risk ventile
| Post-index variablea | Highest risk stratum (20th ventile) | 19th ventile | 11–18th ventiles | Lowest risk stratum (1–10th ventiles) | Overall | ||||
|---|---|---|---|---|---|---|---|---|---|
| Nb | %c | N | % | N | % | N | % | N | |
| Number of patients | 22,672 | 5.0 | 22,672 | 5.0 | 181,376 | 40.0 | 226,719 | 50.0 | 453,439 |
| Study outcomes | |||||||||
| Hypoglycemic event | 3348 | 25.9 | 1797 | 13.9 | 5745 | 44.5 | 2014 | 15.6 | 12,904 |
| Antidiabetic persistence | 2532 | 3.8 | 2590 | 3.9 | 23,250 | 35.1 | 37,790 | 57.1 | 66,162 |
| HbA1c target attainment | 8082 | 6.3 | 7573 | 5.9 | 56,345 | 43.7 | 56,982 | 44.2 | 128,982 |
| HbA1c change from baseline | 1175 | 7.1 | 1177 | 7.2 | 7498 | 45.6 | 6602 | 40.1 | 16,452 |
| T2D-related inpatient admission | 2965 | 9.8 | 2501 | 8.3 | 14,328 | 47.3 | 10,469 | 34.6 | 30,263 |
| T2D-related total medical cost | $4114 | 8.7 | $3509 | 7.4 | $2691 | 45.6 | $1801 | 38.2 | $2358 |
| Visits: all-cause | |||||||||
| Inpatient admissions | 5608 | 10.2 | 4590 | 8.4 | 26,082 | 47.5 | 18,644 | 33.9 | 54,924 |
| ER visits | 7243 | 7.4 | 6451 | 6.6 | 43,955 | 44.9 | 40,313 | 41.2 | 97,962 |
| Outpatient visits | 22,420 | 5.1 | 22,376 | 5.1 | 177,857 | 40.3 | 218,783 | 49.6 | 441,436 |
| Visits: hypoglycemia-related | |||||||||
| Inpatient admissions | 501 | 26.7 | 254 | 13.5 | 886 | 47.2 | 236 | 12.6 | 1877 |
| ER visits | 570 | 24.7 | 323 | 14.0 | 1144 | 49.6 | 271 | 11.7 | 2308 |
| Outpatient visits | 2164 | 27.4 | 1192 | 15.1 | 3381 | 42.9 | 1153 | 14.6 | 7890 |
| Costs | |||||||||
| Healthcare | $36,567 | 10.7 | $30,090 | 8.8 | $19,406 | 45.4 | $12,038 | 35.2 | $17,114 |
| Medical | $28,652 | 11.3 | $23,081 | 9.1 | $14,173 | 44.8 | $8825 | 34.8 | $12,669 |
| Pharmacy | $7915 | 8.9 | $7009 | 7.9 | $5233 | 47.1 | $3213 | 36.1 | $4446 |
| Hypoglycemia-related medical | $395 | 30.1 | $167 | 12.7 | $75 | 45.6 | $15 | 11.6 | $66 |
aAll variables were collected in the 1 year following the index date
bRepresents the count of patients with the relevant study outcome event or visit within ventiles. Patients with multiple visits were only counted once. For cost variables, represents the average costs per patient per year ($/PPY) within ventiles
cRepresents the percentage of patients with the relevant study outcome event or visit within ventiles out of the total number of relevant study outcome events or visits. For costs, represents the percentage of costs within ventiles out total costs