Table 1.

Simple person-led titration algorithms in key clinical trials

Study	Dose adaptation (patient-led titration algorithm)
2 units dose adaptation every 3 days	AT.LANTUS [10]
2–4 units dose adaptation every 3 days	LANMET [9] and INITIATE [15]
3 units dose adaptation every 3 days	PREDICTIVE 303 [16]

AT.LANTUS A Trial comparing Lantus Algorithms to achieve Normal glucose Targets in subjects with Uncontrolled blood Sugar, LANMET LANntus plus METformin, INITIATE INITiate Insulin by Aggressive Titration and Education, PREDICTIVE 303 Predictable Results and Experience in Diabetes through Intensification and Control to Target: An International Variability Evaluation 303