Table 3.

The influence of active ingredients-miRNA in TCM on cardiovascular diseases.

Active components	Cell types	MiRNAs	Targets	Effects (references)
Tanshinone IIA	Macrophages	miR-375	KLF4	Anti-AS [33]
	NRCMs	miR-133	MAPK ERK1/2	Protecting cardiomyocytes [34]
	H9c2	miR-152-3p	PTEN	Inhibiting apoptosis [35]
Salvianolate	H9c2	miR-122-5p	Bax, Bcl-2	Inhibiting apoptosis [36]
Astragaloside IV	H9c2	miR-23a/miR-92a.	PI3K/AKT	Protects rat cardiomyocytes [37]
Notoginsenoside R1	H9c2	miR-21	PI3K/AKT	Cardioprotective actions [38]
Ginsenoside Rb1	NRCMs	miR-208	—	Protecting H/I impaired NRCMs [39]
Ginkgolide B	EPC	miR-126	Akt	Promoted cell growth [40]
Crataegus special extract	HUVEC	miR-155	eNOS	Protecting vascular [41]

EPC: endothelial progenitor cells; HUVEC: human umbilical vein endothelial cells; NRCMs: neonatal rat cardiomyocytes.