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. 2020 Feb 28;11:1141. doi: 10.1038/s41467-020-14870-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Representative immunohistochemical staining images of both CBX4 and CK1α for 55 paraffin-embedded osteosarcoma tissues. Scale bar: 100 μm. b A positive correlation was observed between CBX4 and CK1α protein levels in the osteosarcoma tissues used in a (p = 0.022, χ² tests. R: Spearman correlation coefficient). *p < 0.05 using the two-sided Pearson chi-squared tests. c–f Overall survival curves were generated based on the protein levels of CK1α (c, e) or CBX4 (d, f) in the osteosarcoma tissues used in a. *p < 0.05 using Kaplan–Meier plots and compared with the log-rank test.