Table 1.
Baseline characteristics of the study population.
| Variables | Lowest MLR tertile | Middle MLR tertile | Highest MLR tertile | P value |
|---|---|---|---|---|
| MLR < 0.29 (n = 583) | MLR 0.29-0.45 (n = 585) | MLR > 0.45 (n = 585) | ||
| Age (years) | 49.6 ± 14.9 | 49.8 ± 14.7 | 53.8 ± 14.8 | <0.001 |
| Male sex (%) | 272 (46.7) | 346 (59.1) | 379 (64.8) | <0.001 |
| Hypertension (%) | 408 (0.70) | 404 (69.1) | 432 (73.8) | 0.160 |
| A history of CVD (%) | 108 (18.5) | 89 (15.2) | 104 (17.8) | 0.290 |
| Diabetes (%) | 129 (22.1) | 129 (22.1) | 160 (27.4) | 0.051 |
| CCI | 4.16 ± 1.75 | 4.09 ± 1.69 | 4.62 ± 1.78 | <0.001 |
| Current smoking (%) | 26 (4.5) | 32 (5.5) | 29 (5.0) | 0.729 |
| Current drinking (%) | 5 (0.9) | 12 (2.1) | 8 (1.4) | 0.225 |
| ACEI/ARB use (%) | 195 (33.0) | 195 (33.0) | 213 (36.4) | 0.455 |
| β-Blocker use (%) | 134 (23.0) | 112 (19.1) | 140 (23.9) | 0.112 |
| Statin use (%) | 69 (11.8) | 72 (12.3) | 94 (16.1) | 0.067 |
| BMI (kg/m2) | 22.3 ± 3.6 | 22.3 ± 3.2 | 22.2 ± 3.7 | 0.906 |
| Systolic BP (mmHg) | 150 ± 26 | 148 ± 27 | 149 ± 25 | 0.477 |
| Diastolic BP (mmHg) | 88 ± 15 | 87 ± 16 | 87 ± 15 | 0.778 |
| 24 h urine output (ml) | 600 (200-1050) | 700 (300-1100) | 650 (200-1000) | 0.062 |
| Monocytes (∗109/l) | 0.47 ± 0.24 | 0.45 ± 0.23 | 0.50 ± 0.25 | 0.003 |
| Lymphocytes (∗109/l) | 1.30 ± 0.52 | 1.28 ± 0.52 | 1.20 ± 0.48 | 0.005 |
| Albumin (g/dl) | 3.35 ± 0.78 | 3.39 ± 0.72 | 3.30 ± 0.67 | 0.107 |
| Cholesterol (mg/dl) | 151 ± 67 | 152 ± 62 | 156 ± 66 | 0.421 |
| Triglycerides (mg/dl) | 125 ± 99 | 130 ± 99 | 127 ± 89 | 0.686 |
| LDL (mg/dl) | 2.55 ± 1.02 | 2.52 ± 0.95 | 2.60 ± 1.03 | 0.506 |
| HDL (mg/dl) | 1.14 ± 0.39 | 1.14 ± 0.38 | 1.13 ± 0.37 | 0.411 |
| Serum uric acid (mg/dl) | 7.06 ± 2.42 | 7.34 ± 2.35 | 7.14 ± 2.42 | 0.118 |
| hs-CRP (mg/l) | 21.8 (5.40-82.7) | 9.9 (2.4-37.2) | 6.6 (2.3-22.6) | 0.746 |
| NT-pro-BNP (pg/ml) | 3207 (1141-8789) | 2810 (504-14675) | 2135 (1034-5757) | 0.464 |
| eGFR (ml/min/1.73 m2) | 5.71 (4.31–8.40) | 5.69 (4.29–8.64) | 5.68 (4.23–7.44) | 0.367 |
MLR: monocyte-to-lymphocyte ratio; CVD: cardiovascular disease; CCI: Charlson comorbidity index; ACEI/ARB: angiotensin-converting enzyme inhibitor/angiotensin receptor blocker; BP: blood pressure; LDL: low-density lipoprotein; HDL: high-density lipoprotein; hs-CRP: high-sensitivity C-reactive protein; NT-pro-BNP: N-terminal probrain natriuretic peptide; eGFR: estimated glomerular filtration rate.