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. Author manuscript; available in PMC: 2020 May 23.
Published in final edited form as: J Med Chem. 2018 Dec 27;62(10):4851–4883. doi: 10.1021/acs.jmedchem.8b00843

Table 2:

Potency values obtained for EFV and RPV using a single infectivity assay in wild-type and mutant RTs.132

Reverse Transcriptase EFV (EC50, nM) RPV (EC50, nM)
wild-type 15 13
K103N 806 13
K101P 870 1142
Y181C 41 51