Table 1.

Summary of the early host immune response to Multidomain Peptide hydrogels displaying different chemical functionalities.

Peptide	K2	R2	E2	D2
Cellular infiltration	++	+++	+	+
Degradation	++	+	+++	+++
Collagen deposition	++	+++	−	−
Inflammation	++	+++	+	+
Angiogenesis	+	+	−	−
Inflammatory cytokines Main inflammatory cell*	++	+++	+	+
Day 1	Monocytes	PMN-MDSC	−	−
Day 3	Monocytes	PMN-MDSC	Macrophages	−
Day 7	Macrophages	PMN-MDSC	Macrophages	Macrophages
Day 10	Macrophages	PMN-MDSC	−	−
Resolution of inflammation	++	+	+++	+++

^*Main inflammatory cell at the specific time point, Phenotypes are: Monocytes: CD45⁺ CD11b⁺ Gr-1⁺ Ly6C^high-med; Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC): CD45⁺ CD11b⁺ Gr-1⁺ Ly6C^low-neg; Macrophages: CD45⁺ CD11b⁺ Gr-1^neg F4/80⁺.