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. 2020 Feb 11;117(8):4320–4327. doi: 10.1073/pnas.1913810117

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Copyright © 2020 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Fig. 6. — CLL-derived IGLV3-21^R110 LC boosts autonomous signaling. (A, Left and Middle) BCR expression (IgM HC and Igλ LC) in TKO cells reconstituted with CLL-derived HCs together with reverted IGLV3-21^G110 (Left) or IGLV3-21^R110 (Middle) LC variants. (A, Right) Overlaid immunophenotyping histograms analyzing the IGLV3-21^R110 expression in the same reconstituted TKO cell using a fluorescently labeled anti-R110 antibody. (B) Exemplary Ca²⁺ release kinetics of the original BCR derived from UM-CLL (LS #83) revealing autonomous BCR signaling and containing an R110-mutated LC (IGLV3-21^R110; Left) as compared with the reverted LC containing a germline G110 (IGLV3-21^G110; Right).