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. 2020 Feb 10;117(8):4262–4272. doi: 10.1073/pnas.1917203117

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Fig. 4. — Chronic stress leads to heavier tumor burden in gut-deleted Xist-mutant females. (A) Xist RT-qPCR for colon epithelial samples; n = 2. Data represent mean ± SEM. (B) Kaplan–Meier survival curve for unstressed animals (not treated with AOM/DSS). (C) AOM/DSS chemical induction protocol. (D) Whole colon from control and Xist^fl/fl; Villin-Cre females and Xist^fl/Y; Villin-Cre males. (Scale bar, 1 cm.) Three age- and litter-matched biological replicates (mutant female mice) shown. (E) Average polyp diameter in colons of control vs. mutant animals. *P < 0.05 (Student’s t test); n.s, not significant. (F) Average number of polyps in colons of control vs. mutant animals.