. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Alzheimers Dement. 2019 Jul;15(7):907–916. doi: 10.1016/j.jalz.2019.04.005

Table 2.

Hazard Ratios for the association of AD Genetic Risk Score (AD GRS) with all-cause, dementia-related and non-dementia related mortality.

	All- Cause Mortality	Dementia-Related Mortality	Non-Dementia Related Mortality
	HR (95% CI)	HR (95% CI)	HR (95% CI)

Model 1
AD-GRS	1.07 (1.02–1.13)	1.99 (1.66,2.39)	1.03 (0.97, 1.08)
Model 2
AD-GRS	1.07 (1.02,1.13)	1.99 (1.66,2.40)	1.03 (0.97, 1.08)
Low Education	1.28 (1.23, 1.34)	1.08 (0.91, 1.29)	1.29 (1.24, 1.35)
Model 3
AD-GRS	1.12 (1.03,1.22)	2.02 (1.50,2.71)	1.07 (0.98, 1.17)
Low Education	1.29 (1.21, 1.34)	1.08 (0.90, 1.30)	1.30 (1.25, 1.35)
AD-GRS by Low Education Interaction	0.93 (0.84, 1.03)	0.98 (0.67, 1.44)	0.94 (0.84, 1.04)
AD-GRS Effect Estimates Among High and Low Education Groups, Estimated from Model 3
AD-GRS in High Education	1.12 (1.03,1.22)	2.02 (1.50,2.71)	1.07 (0.98, 1.17)
AD-GRS in Low Education	1.05 (0.99,1.11)	1.98 (1.56,2.51)	1.01 (0.94, 1.07)
P_interaction	0.19	0.63	0.21