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. Author manuscript; available in PMC: 2020 Feb 29.
Published in final edited form as: ACS Nano. 2018 Dec 4;13(1):357–370. doi: 10.1021/acsnano.8b06400

Figure 5.

Figure 5.

Rapid intracellular disintegration of P6 NPs accompanied by a GSH-exhausting effect. (a) A2780 and A2780cis cells incubated with Coumarin 6 and Nile red-P6 NPs for 4 and 18 h. To investigate the effect of GSH on NP disintegration, cells were also pretreated with NEM to consume cytosolic GSH. Images were taken under a 60× objective. (b, c) GSH and (d, e) GSSG percent of (b, d) A2780 and (c, e) A2780cis cells treated with cisplatin, P6 NPs, or P6 Soln at Pt concentrations of 0, 1.56, 6.25, or 25 μM.