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. 2020 Feb 29;17:75. doi: 10.1186/s12974-019-1616-z

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effects of cinobufagin on spinal gene (a–c) and protein (d, e) expression of IL-10, β-endorphin and dynorphin A in bone cancer pain rats. The spinal lumbar enlargement (L3-L5) of female bone cancer pain rats were collected 1 h after intrathecal injection of cinobufagin. The mRNA expression of IL-10, the β-endorphin precursor proopiomelanocortin (POMC) and dynorphin precursor prodynorphin (PDYN), and protein expression of IL-10 and β-endorphin were measured by using qRT-PCR and commercial fluorescent immunoassay kits, respectively. The data are presented as means ± SEM (n = 6 per group). The asterisk denotes statistical significance (p < 0.05) compared to the saline control group, by unpaired and two-tailed Student t test