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. 2020 Feb 28;11:91. doi: 10.1186/s13287-020-01612-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The modulatory effect of HGF secreted by MSCs on Th17/Treg cell differentiation in CD4+ T cells analysed by flow cytometry. The results showed that the percentage of CD4+CD25+Foxp3+ cells was significantly increased in the CD4+ T cell population, but the MSC-induced effect was significantly inhibited by an anti-HGF antibody (p < 0.05, a, c). The percentage of CD4+CD3+RORrt+ cells was significantly decreased after MSC coculture. However, the MSC-induced effect was significantly inhibited by the anti-HGF antibody (p < 0.05, b, d) (n = 3; *p < 0.05 or **p < 0.01 vs. the CD4+ group; ^#p < 0.05 vs. the MSC+CD4+ group). MSCs, mesenchymal stem cells; rmHGF, recombinant mouse hepatocyte growth factor