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. 2020 Feb 28;11:91. doi: 10.1186/s13287-020-01612-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The regulatory effect of HGF secreted by MSCs on cytokine mRNA expression in CD4+ T cells analysed by qPCR. The results showed that MSCs significantly increased IL-10 (p < 0.05, a) and TGF-β (p < 0.01, b) mRNA expression and inhibited IL-17 (p < 0.01, c) and IL-6 (p < 0.05, d) mRNA expression in CD4+ T cells. However, the MSC-induced effects were inhibited by an anti-HGF antibody (p < 0.05 or p < 0.01) (n = 3; *p < 0.05 or **p < 0.01 vs. the CD4+ group; ^#p < 0.05 or ^##p < 0.01 vs. the MSC+CD4+ group). MSCs, mesenchymal stem cells; rmHGF, recombinant mouse hepatocyte growth factor; qPCR, quantitative polymerase chain reaction