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. 2020 Feb 29;17:11. doi: 10.1186/s12987-020-0171-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Abundant pinocytotic vesicles in endothelial cells in PTS. Blood vessels in healthy spinal cord tissue show a limited number of intracellular vesicles (a). In tissue from PTS animals, some blood vessels contained abundant electron-lucent vesicles indicated by black arrows (b–d). Intracellular vesicles fusing with the endothelial plasma membrane (c). Note the blood vessel in (d) also shows a microcavity in the perivascular region, suggesting that the two processes may be related. EC, endothelial cell; L, lumen; *, perivascular microcavity. Magnification: ×19,000 (a), ×34,000 (b), ×64,000 (c), ×10,500 (d). Scale bars: 0.5 µm (a), 0.2 µm (b), 0.1 µm (c), 1 µm (d)