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. 2020 Feb 29;17:11. doi: 10.1186/s12987-020-0171-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Abnormalities in the BSCB in PTS. Typical appearance of an occluding tight junction (black arrowhead) between capillary endothelial cells (EC), in the spinal cord of a healthy rat (a). Examples of abnormal capillaries in the rat spinal cord with PTS. The typical tight junctions between endothelial cells are not visible, and instead the intercellular junction is characterized by local swelling and dilation (black arrows). The intra- and extra-luminal spaces appear to be in continuity (b). L, lumen. Magnification: ×46,000 (a), ×64,000 (b). Scale bars: 0.2 µm (a), 0.1 µm (b)