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. 2019 Dec 16;38(7):674–685. doi: 10.1200/JCO.19.01907

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© 2019 by American Society of Clinical Oncology

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FIG 1. — Estimated absolute risk of developing breast cancer for women with germline PALB2 pathogenic variants (PVs) by age under (A) a model that assumes no cohort effect (blue, the risk for women with PALB2 PVs; red, the risk in the United Kingdom general population, assuming that population incidences are applicable to individuals born between 1950 and 1959) and (B) a model that allows for cohort-specific relative risk parameters. The dotted curves and shaded area show the 95% CI. (*) Assuming that the relative risk estimates apply to the unobserved age ranges for women born in these cohorts.