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. 2020 Feb 25;14:773–782. doi: 10.2147/DDDT.S229270

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© 2020 Li et al.

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Effect of fisetin treatment on cleavage of caspase 3 and PARP in PAK4-overexpressing OSCC cells.

Notes: After treatment with the indicated concentration of fisetin for 24 h, (A) SCC9-PAK4-Lv and (C) SCC4-PAK4-Lv cells were harvested, whole cells were lysed, and the expression of full-length and cleaved PARP was determined. β-actin was used as a loading control. Expression of cleaved PARP was measured with ImageJ; the relative cleaved PARP/β-actin ratios are shown in (B and D). **P < 0.01 vs. DMSO. (E) In SCC9-PAK4-Lv cells, the expression of full-length and cleaved caspase 3 was detected. GAPDH was used as a loading control protein. The statistical graphs are shown in the right panel (*P < 0.05 and **P < 0.01, compared with DMSO).