Table 1.
Characteristics of Patients with COPD and Healthy Subjects
| Variables | Heathy Controls (n=68) | Stable COPD (n=100) | AECOPD (n=130) | P |
|---|---|---|---|---|
| Sex (male/female) | 38/30 | 78/22 | 95/35 | 0.006a |
| Age | 52.85±14.22 | 63.34±9.94 | 71.28±9.94 | <0.001 |
| BMI | 24.91±3.86 | 23.14±3.01 | 23.07±3.57 | 0.001b |
| Smoking status(S/NS) | 23/45 | 76/24 | 89/41 | <0.001a |
| Pack-years for ever-smokers | 33.53±35.77 | 38.96±24.08 | 35.70±24.70 | 0.134 |
| FEV1/FVC, % | 86.18±7.44 | 49.73±12.41 | <0.001b | |
| FEV1%pre | 102.50±17.95 | 53.17±21.52 | <0.001 | |
| MEF75 | 85.84±23.55 | 27.07±19.89 | <0.001 | |
| MEF50 | 91.59±28.71 | 17.52±12.08 | <0.001 | |
| MEF25 | 97.76±42.92 | 17.06±11.21 | <0.001 | |
| MEF75/25 | 88.83±29.15 | 16.40±10.61 | <0.001 | |
| CAT | 4.31±6.57 | 14.63±6.58 | <0.001 | |
| WBC, 109/L | 5.64±1.57 | 6.37±1.85 | 7.74±3.43 | <0.001 |
| VEGF (pg/mL) | 91.62±57.87 | 115.22±87.13 | 144.00±99.54 | <0.001 |
| CRP (ug/mL) | 1.50±1.67 | 3.56±4.96 | 3.79±2.23 | <0.001 |
| LDL (mmo/L) | 2.40±0.70 | 2.03±0.84 | 2.29±0.77 | 0.007b |
| Endostatin(ng/mL) | 68.86±29.17 | 89.29±30.33 | 102.09±36.59 | <0.001b |
Notes: Continuous data were presented as mean ± standard deviation (SD), whereas categorical data were expressed as frequency. aχ2 test was used to test the significance of the difference in sex proportions and smoking status. aThe data were analyzed by Chi-square tests. bThe data were analyzed by one-way analysis of variance.
Abbreviations: COPD, chronic obstructive pulmonary disease; AECOPD, acute exacerbation of COPD; BMI, body mass index; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; MEF75, maximum expiratory flow at 75%; MEF50, maximum expiratory flow at 50%; MEF25, maximum expiratory flow at 25%; WBC, white blood cells; CRP, C-reactive protein; VEGF, vascular endothelial growth factor; LDL, Low-Density Lipoprotein.