Table 2.
Univariate and multivariate Cox regression analyses for overall survival of HCC with PVTT in the derivation cohort.
| Variable | Univariate Cox | Multivariate Cox | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Median age | 0.994 | (0.975–1.013) | 0.550 | |||
| Gender | 0.936 | (0.725–1.208) | 0.610 | |||
| HBV related | 1.130 | (0.609–2.097) | 0.699 | |||
| Cirrhosis | 1.015 | (0.776–1.327) | 0.923 | |||
| Comorbidity index | 0.980 | (0.810–1.180) | 0.802 | |||
| ALT ≥ 70 IU/L | 2.006 | (1.411–2.852) | <0.001 | |||
| AST ≥ 119 IU/L | 2.849 | (2.003–4.053) | <0.001 | 1.766 | (1.194–2.611) | 0.004 |
| GGT ≥ 115 IU/L | 2.679 | (1.727–4.155) | <0.001 | 2.037 | (1.265–3.279) | 0.003 |
| Child–Pugh class C | 2.955 | (1.958–4.459) | <0.001 | 3.294 | (2.075–5.227) | <0.001 |
| WBC ≥ 4.3 × 109/L | 2.075 | (1.394–3.088) | <0.001 | |||
| Cr ≥ 91 μmoI/L | 1.757 | (1.099–2.808) | 0.018 | 2.578 | (1.573–4.223) | <0.001 |
| Portal vein invasion Vp4 | 0.890 | (0.613–1.290) | 0.537 | |||
| AFP ≥ 400 ng/ml | 1.900 | (1.335–2.703) | <0.001 | 1.545 | (1.073–2.227) | 0.020 |
| Tumor number ≥ 3 | 1.491 | (1.041–2.135) | 0.029 | |||
| Largest tumor diameter ≥ 5 cm | 2.129 | (1.436–3.157) | <0.001 | 2.784 | (1.804–4.296) | <0.001 |
| Lymph node metastasis | 0.942 | (0.579–1.532) | 0.809 | |||
HR, hazard ratios; CI, confidence interval.