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. 2019 May 30;105(3):623–631. doi: 10.3324/haematol.2018.213462

Figure 3.

Figure 3

Treatment of phosphodiesterase 9A inhibitor (IMR-687) in sickle mice for 30 days results in reduced immune cell activity. White blood cell (WBC) counts are elevated in Townes-HbSS mice above normal controls (A). Townes-HbSS mice were dosed orally for 30 days with IMR-687 at 30 mg/kg or hydroxyurea (HU) at 100 mg/kg. Treatment with IMR-687 or HU reduced circulating WBC counts (A) (n=3). NS: not significant; *P>0.05. Data are presented as means±Standard Errors. This decrease in WBC counts is not seen in normal mice, rats or dogs dosed with IMR-687, including long-term 9-month toxicology studies in dogs dosed orally daily with 10, 25, or 50 mg/kg of IMR-687 (B). Along with the reduction in circulating WBC levels in IMR-687-treated Townes mice, there was a significant reduction in lung myeloperoxidase activity (C) (n=7). **P<0.01; ***P<0.001; ns: not significant (P>0.05). Data are presented as means±Standard Errors. MPO: myeloperoxide.