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. 2019 May 30;105(3):585–597. doi: 10.3324/haematol.2018.197210

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Systemic inflammation in mice with collagen-induced arthritis. (A) Experimental design. (B) Cytokine levels in serum from control mice (Ctrl) and mice with collagen-induced arthritis (CIA) (n=7 Ctrl and 4 CIA). Serum sample data were compiled from two independent experiments. (C,D) Gene expression analysis of hematopoietic stem cells (HSC) from Ctrl and CIA mice showing (C) IFN/STAT signaling genes and (D) IL-1/TNF signaling genes. The data are presented as log₁₀ fold expression in CIA HSC versus Ctrl HSC. (n=14-16 per group) *P<0.05; **P<0.01, as determined by the Mann-Whitney U-test.