Table 1.
Adult Angiostrongylus vasorum worm counts in Study 1: percent efficacy and statistical comparisons to placebo
| Treatment | Moxidectin dose (µg/kg)a | Geometric mean worm count | % Efficacy | Test statistic |
|---|---|---|---|---|
| Placebo | 0 | 53.8 | – | – |
| Sarolaner + moxidectin + pyrantel | 3 | 49.9 | 7.2 |
t(21) = 0.23, P = 0.8169 |
| Sarolaner + moxidectin + pyrantel | 12 | 24.4 | 54.5 |
t(21) = 2.45, P = 0.0234 |
| Sarolaner + moxidectin + pyrantel | 24 | 2.9 | 94.7 |
t(21) = 8.47, P < 0.0001b |
aThe combination product-treated dogs received the exact moxidectin dose shown for each group, combined with 2 mg/kg sarolaner and 5 mg/kg pyrantel
bAdult worm counts significantly lower compared to the 3 µg/kg and the 12 µg/kg groups (6.02 ≤ t(21) ≤ 8.23, P < 0.0001)