Table 2.

Arithmetic mean flea counts and percent efficacy relative to placebo at 24 h after treatment and weekly re-infestations with Ctenocephalides felis for dogs treated orally with Simparica Trio™, sarolaner-only, moxidectin-only or pyrantel-only tablets (Study 2)

Day after treatment	Treatment group	Flea count	% Efficacy
1	Placebo	70.1	–
	Simparica Trio™	0*	100
	Sarolaner	0*	100
	Moxidectin	65.5	6.6
	Pyrantel	66.6	5.0
7	Placebo	78.3	–
	Simparica Trio™	0*	100
	Sarolaner	1.9*	97.6
	Moxidectin	66.4	15.2
	Pyrantel	73.8	5.8
14	Placebo	65.8	–
	Simparica Trio™	0*	100
	Sarolaner	0*	100
	Moxidectin	70.6	0
	Pyrantel	76.8	0
21	Placebo	54.1	–
	Simparica Trio™	0.1*	99.8
	Sarolaner	0.4*	99.3
	Moxidectin	64.8	0.0
	Pyrantel	71.8a	0.0
28	Placebo	86.6	–
	Simparica Trio™	0.3*	99.7
	Sarolaner	0*	100
	Moxidectin	78.9	8.9
	Pyrantel	63.5b	26.7
35	Placebo	79.6	–
	Simparica Trio™	0*	100
	Sarolaner	0.4*	99.5
	Moxidectin	79.4	0.3
	Pyrantel	87.8	0

*Flea counts are significantly lower than placebo; 7.78 ≤ t₍₃₅₎ ≤ 10.42, P < 0.0001

^aFlea count significantly higher than placebo; t₍₃₅₎ = − 3.00, P = 0.005

^bFlea count significantly lower than placebo; t₍₃₅₎ = 2.78, P = 0.0087