Table 3.
Arithmetic mean flea counts (percent efficacy) relative to placebo for dogs treated orally with Simparica Trio™ at 3, 4, 8 or 12 h after treatment (Day 0) and weekly re-infestations with Ctenocephalides felis (Study 4)
| Count time | Treatment group | Day after treatment | |||||
|---|---|---|---|---|---|---|---|
| 0 | 7 | 14 | 21 | 28 | 35 | ||
| 3 h | Placebo | 77.1 | 95.0 | 89.0 | 93.8 | 90.4 | 98.8 |
| Simparica Trio™ |
77.8 (0) |
61.6b (35.1) |
50.1b (43.7) |
88.3 (5.9) |
92.8 (0) |
93.0 (5.8) |
|
| 4 h | Placebo | 72.4 | 94.1 | 89.5 | 93.1 | 95.9 | 97.4 |
| Simparica Trio™ |
42.8a (40.9) |
43.6b (53.7) |
31.3b (65.1) |
72.1b (22.6) |
85.9 (10.4) |
95.9 (1.5) |
|
| 8 h | Placebo | 84.0 | 88.9 | 89.1 | 87.8 | 94.0 | 94.1 |
| Simparica Trio™ |
0b (100) |
0.4b (99.6) |
6.9b (92.3) |
3.6b (95.9) |
26.6b (71.7) |
70.4b (25.2) |
|
| 12 h | Placebo | 85.0 | 93.1 | 86.6 | 92.0 | 96.0 | 95.3 |
| Simparica Trio™ |
0b (100) |
0b (100) |
0b (100) |
0b (100) |
2.1b (97.8) |
13.8b (85.6) |
|
aMean live flea counts significantly lower than placebo; t(53) = 4.16, P = 0.0001
bMean live flea counts significantly lower than placebo; 10.09 ≤ tdf ≤ 41.72, 7 ≤ df ≤ 56, P ≤ 0.0138