Table 1.

The major genetic aberrations identified in Hodgkin’s lymphoma.

Lymphomatype	Gene	Genetic aberration	Frequency of mutated cases (%)	Dysregulated biological process or pathway	References
Hodgkin’s lymphoma	REL	Amplification	~50	NF-κB pathway	Barth et al., 2003
	NFKBIA, NFKBIE, TNFAIP3	Point mutations, deletions	50–60		Weniger et al., 2016
	MDM2	Gains	60	P53-dependent biological processes (e.g., cell cycle arrest and apoptosis)	Küppers, 2009
	TP53	Point mutations, deletions	10
Classical Hodgkin’s lymphoma	JAK1, STAT3, STAT5B	Missense mutations	15	JAK-STAT pathway	Tiacci et al., 2018
	JAK2	Gains	32
	PTPN1	Splice-acceptor, missense mutations	6
	SOCS1	Frameshift mutations, disruptive in-frame deletions, splice donor, missense	47	JAK-STAT5pathway	Weniger et al., 2006;Tiacci et al., 2018
EBV+ Hodgkin’s lymphoma	LMP2A	EBV-encoded LMP2A mediated transcriptional changes	~50	Transcriptional signature similar to that of HRS* cells	Portis et al., 2003

*: Reed–Sternberg cells of Hodgkin’s lymphoma.