Table 3. Top 20 enriched biological pathways.
Ranking of the enriched biological pathways is based on NES and FDR value. The enriched biological pathways (KEGG) by the enrichment analysis were found under statistically significant levels (FDR ¡ 0.05) except those indicated with asterisk (*: 0.05 < P < 0.13; 0.12 < FDR < 0.21).
| Ag | SiO2 | ||||||
|---|---|---|---|---|---|---|---|
| Biological pathway | NES | Rank | Biological pathway | NES | Rank | ||
| Positive enrichment | Ribosome | 7.179 | 1 | Ribosome | 6.864 | 1 | |
| Proteasome | 4.731 | 2 | Proteasome | 3.682 | 2 | ||
| Rna transport | 4.484 | 3 | Aminoacyl-trna biosynthesis | 3.296 | 3 | ||
| Spliceosome | 4.453 | 4 | Oxidative phosphorylation | 2.986 | 4 | ||
| Oxidative phosphorylation | 4.320 | 5 | Carbon metabolism | 2.969 | 5 | ||
| Aminoacyl-trna biosynthesis | 4.078 | 6 | Rna transport | 2.955 | 6 | ||
| Ribosome biogenesis in eukaryotes | 3.661 | 7 | Pyruvate metabolism | 2.724 | 7 | ||
| Nucleotide excision repair | 3.643 | 8 | Rna polymerase | 2.439 | 8 | ||
| Carbon metabolism | 3.458 | 9 | Fanconi anemia pathway | 2.337 | 9 | ||
| Glycosylphosphatidylinositol (gpi)-anchor biosynthesis | 3.349 | 10 | Ribosome biogenesis in eukaryotes | 2.333 | 10 | ||
| Fanconi anemia pathway | 3.330 | 11 | Fatty acid metabolism | 2.280 | 11 | ||
| Dna replication | 3.316 | 12 | Nucleotide excision repair | 2.170 | 12 | ||
| Pyrimidine metabolism | 3.141 | 13 | Pyrimidine metabolism | 2.169 | 13 | ||
| Rna polymerase | 3.021 | 14 | Fatty acid degradation | 2.160 | 14 | ||
| Mrna surveillance pathway | 2.926 | 15 | Rna degradation | 2.157 | 15 | ||
| Endocytosis | 2.840 | 16 | Valine, leucine and isoleucine degradation | 2.144 | 16 | ||
| Rna degradation | 2.816 | 17 | Biosynthesis of amino acids | 2.140 | 17 | ||
| Mismatch repair | 2.762 | 18 | Glycosylphosphatidylinositol (gpi)-anchor biosynthesis | 2.087 | 18 | ||
| Homologous recombination | 2.747 | 19 | Dna replication | 2.066 | 19 | ||
| Peroxisome | 2.699 | 20 | Glycolysis / gluconeogenesis | 2.065 | 20 | ||
| Negative enrichment | |||||||
| Neuroactive ligand–receptor interaction | −2.490 | 1 | Protein processing in endoplasmic reticulum | −3.896 | 1 | ||
| Wnt signaling pathway | −2.350 | 2 | Endocytosis | −3.374 | 2 | ||
| Lysosome | −2.199 | 3 | Spliceosome | −3.298 | 3 | ||
| Ecm-receptor interaction | −2.180 | 4 | Wnt signaling pathway | −3.199 | 4 | ||
| Phagosome | −2.118 | 5 | Ubiquitin mediated proteolysis | −2.849 | 5 | ||
| Mapk signaling pathway | −1.973 | 6 | Tgf-beta signaling pathway | −2.782 | 6 | ||
| Calcium signaling pathway | −1.921 | 7 | Mrna surveillance pathway | −2.738 | 7 | ||
| Drug metabolism - cytochrome p450 | −1.872 | 8 | Mapk signaling pathway | −2.600 | 8 | ||
| Autophagy - animal | −1.726 | 9 | Calcium signaling pathway | −2.248 | 9 | ||
| Age-rage signaling pathway in diabetic complications | −1.713 | 10 | Ecm-receptor interaction | −2.077 | 10 | ||
| Tgf-beta signaling pathway | −1.667 | 11 | Phosphatidylinositol signaling system | −2.068 | 11 | ||
| Glycosphingolipid biosynthesis - globo and isoglobo series | −1.593 | 12 | Notch signaling pathway | −1.951 | 12 | ||
| Erbb signaling pathway | −1.590 | 13 | Autophagy - other | −1.946 | 13 | ||
| Polyketide sugar unit biosynthesis | −1.589 | 14 | Hippo signaling pathway -multiple species | −1.913 | 14 | ||
| Taurine and hypotaurine metabolism* | −1.601 | 15 | Autophagy - animal | −1.866 | 15 | ||
| Glycosaminoglycan degradation* | −1.578 | 16 | Inositol phosphate metabolism | −1.839 | 16 | ||
| Autophagy - other* | −1.450 | 17 | Neuroactive ligand–receptor interaction | −1.828 | 17 | ||
| Hippo signaling pathway -multiple species* | −1.433 | 18 | Phagosome | −1.816 | 18 | ||
| Retinol metabolism* | −1.413 | 19 | Mitophagy - animal | −1.804 | 19 | ||
| Mitophagy - animal* | −1.376 | 20 | Basal transcription factors | −1.700 | 20 | ||