Table 3. Risk factors for major adverse cardiovascular events (MACE) in Cox univariate and multivariate analyses.

Factor	Univariate analysis			Multivariate analysis
	HR	95% CI	p-value	HR	95% CI	p-value
Age (year)	1.045	1.036–1.054	< 0.001	1.031	1.020–1.042	< 0.001
Sex (male)	1.149	0.956–1.381	0.138
Ankle brachial pressure index	0.428	0.331–0.553	< 0.001	0.642	0.437–0.943	0.024
Critical limb ischemia	2.337	1.973–2.769	< 0.001	1.276	0.971–1.676	0.080
History of stroke or TIA	1.498	1.250–1.796	< 0.001	0.988	0.775–1.260	0.923
Coronary heart disease	1.306	1.124–1.517	< 0.001	1.542	1.252–1.898	< 0.001
Diabetes	1.283	1.102–1.493	0.001	1.422	1.161–1.741	0.001
GNRI	0.950	0.941–0.958	< 0.001	0.974	0.962–0.987	< 0.001
eGFR (mL/min/1.73 m2)	0.987	0.984–0.991	< 0.001	0.994	0.990–0.998	0.005
C-reactive protein (mg/dL)	1.161	1.121–1.202	< 0.001	1.129	1.074–1.186	< 0.001
D-dimer (µg/dL)	1.015	1.007–1.024	< 0.001	1.004	0.991–1.018	0.525
Statin	0.330	0.276–0.394	< 0.001	0.384	0.306–0.482	< 0.001
Aspirin	0.858	0.741–0.993	0.040	0.974	0.793–1.196	0.802
Revascularization	0.725	0.624–0.842	< 0.001	0.985	0.945–1.027	0.469

HR: hazard ratio, CI: confidence interval, GNRI: geriatric nutritional risk index, eGFR: estimated glomerular filtration rate