Table 5. Discrimination of each predictive model for all-cause death, major adverse cardiovascular events (MACE), and MACE plus limb events (MACLE) using the C-index and net reclassification index (NRI).
| C-index (95%CI) | p-value | NRI (95%CI) | p-value | |
|---|---|---|---|---|
| All-cause death | ||||
| Established risk factors | 0.8118 (0.7871–0.8366) | Reference | Reference | |
| Established risk factors+BMI | 0.8161 (0.7917–0.8405) | 0.302 | 0.1940 (0.0822–0.3058) | 0.001 |
| Established risk factors+albumin | 0.8171 (0.7929–0.8414) | 0.181 | 0.2185 (0.1076–0.3294) | 0.000 |
| Established risk factors+GNRI | 0.8218 (0.7980–0.8456) | 0.042 | 0.2485 (0.1380–0.3591) | 0.000 |
| MACE | ||||
| Established risk factors | 0.8011 (0.7745–0.8278) | Reference | Reference | |
| Established risk factors+BMI | 0.8022 (0.7758–0.8285) | 0.698 | 0.0950 (−0.0194–0.2094) | 0.104 |
| Established risk factors+albumin | 0.8072 (0.7811–0.8334) | 0.073 | 0.1394 (0.0264–0.2525) | 0.016 |
| Established risk factors+GNRI | 0.8091 (0.7834–0.8348) | 0.043 | 0.1668 (0.0537–0.2799) | 0.004 |
| MACLE | ||||
| Established risk factors | 0.7854 (0.7584–0.8123) | Reference | Reference | |
| Established risk factors+BMI | 0.7893 (0.7628–0.8159) | 0.390 | 0.1344 (0.0195–0.2492) | 0.022 |
| Established risk factors+albumin | 0.7934 (0.7666–0.8201) | 0.110 | 0.1381 (0.0244–0.2518) | 0.017 |
| Established risk factors+GNRI | 0.7984 (0.7723–0.8245) | 0.034 | 0.1992 (0.0859–0.3121) | 0.001 |
Established risk factors included age, ankle brachial pressure index, critical limb ischemia, coronary heart disease, diabetes mellitus, estimated glomerular filtration rate, C-reactive protein, and use of statins.
CI: confidence interval, BMI: body mass index, GNRI: geriatric nutrition risk index