Supplementary Table 2. Differences in condition between human patients and animals used in preclinical studies.

	Humans	Animals
Age	Elder	Young
Presence of other diseases	Having other disease(s)	None
Circadian rhythm	Diurnality	Nocturnal
Genetic homogeneity	Individual differences	Homogenous strain
Gender	Both men and women	Males or females
Cause of disease	Spontaneous or disturbance of the immune or metabolism	Artificial induction or insufficient model
Time to begin treatment	After symptoms progress	At the time of induction or early stage
Drug dose		Extremely high dose

Summarized after van der Worp HB, et al.⁷⁷⁾ and Couzin-Frankel J.⁷⁹⁾.They discussed the difference between human treatment condition and experiments with primarily mice.