Supplementary Table 3. Species differences in lipoprotein metabolism, atherosclerosis, and myocardial characteristics.

	Humans	WHHLMI rabbits	Mice
Lipoprotein metabolism
Main lipoprotein	LDL	LDL	HDL, VLDL with apoB48
ApoB of VLDL	ApoB-100	ApoB-100	apoB-48
Expression of apoB editing enzyme	ilium	ilium	ilium and liver
CETP in plasma	Yes	Yes	none
Hepatic lipase activity in pre-heparin plasma	very low	very low	high
Response to dietary lipid	sensitive	sensitive	resistant
Effects of endothelial lipase on LDL	no effects	no effects	lowering of LDL
Cholesterol-lowering effects of statin	effective	effective	ineffective
Apolipoprotein(a)	Bound to LDL	Bound to LDL	Not bound to LDL
HDL	heterogeneous	heterogeneous	homogenous
Apolipoprotein AII	Dimmer	Absent	Monomer
Hepatic LDL receptor activity	Down regulated	Down regulated	Usually high
Main cholesterol pool	hepatic synthesis	hepatic synthesis	dietary origin
Excretion of bile acid	Low	Low	High
Atherosclerosis
Atherogenesis	Sensitive	Spontaneous	Resistant
Coronary lesions	Frequent	Frequent	Rare
Feature of coronary lesion	Various types	Various types	Excessive lipid deposition
Expression of VLDL receptors in lesions	Macrophages	Macrophages	no expression
Destabilization of plaques by MMPs	Yes	Yes	Inconsistent results
Acute inflammation marker	CRP	CRP	SAP
Cardiac function
Cardiac myosin
Myosin heavy chain	β-type	β-type	α-type
Ion channel of myocardial myosin	Ikr and Iks	Ikr and Iks	Ito and Ik, slow
ECG	12-lead ECG	12-lead ECG	Single lead ECG
Wave form of ECG	T-wave	T-wave	J-wave

Summarized after Fan J, et al.^{84, 85, 87)}, and Shiomi M, et al.⁸⁶⁾