. 2020 Feb 1;27(2):105–118. doi: 10.5551/jat.RV17038-1

Table 1. Lipoprotein metabolism elucidated in studies using WHHL rabbits.

Role of hepatic LDL receptors as a key player in the regulation of plasma cholesterol levels^{12, 36, 37, 40)}
Secretion of VLDL particles from liver and subsequent transformation of VLDL particles into IDL particles³⁶⁾
Rapid uptake of IDL through hepatic LDL receptors⁴⁰⁾, and transformation of remaining IDL particles into LDL particles^{36, 40)}
The relevance of non-expression of apoB-editing enzyme in liver in the accumulation of LDL in the circulation⁴¹⁾
Delay of the maturation of LDL receptor protein39) by small deletions of DNA bases in the LDL binding site of the LDL receptor gene^{38, 72)}