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. 2020 Jan 22;11(3):704–712. doi: 10.1111/1759-7714.13321

Figure 5.

Figure 5

GRP94 promotes cell proliferation and inhibits cell apoptosis in A549 cells. (a) A CCK‐8 method was used to observe the effect of GRP94 on the proliferation of A549 cells. GRP94 gene knockout significantly inhibited A549 cell proliferation (P < 0.05). (b) The effect of GRP94 on lung AD cell apoptosis was evaluated using flow cytometric analysis. GRP94 knockdown had a significant effect on the rate of cell apoptosis (P < 0.01). (c) Western blotting was used to detect apoptosis‐related proteins. GRP94 knockout significantly increased the level of the apoptosis‐inducing proteins, CHOP and caspase‐7. The depletion of GRP94 significantly reduced levels of TGF‐β and SMAD2.