Table 2.

Adverse events of every dosage (n = 28)

Dose	150 mg (n = 2)	200 mg (n = 5)	250 mg (n = 4)	300 mg (n = 17)	Total N (%)
Rash	0	0	2†	3†	5 (17.9%)
Pruritus	1	0	0	2	3 (10.7%)
Skin chapped	0	1	0	1	2 (7.1%)
Liver function abnormal	2	2	3	3	10 (35.7%)
Nausea/vomiting	1	0	1	1	3 (10.7%)
Abdominal distention	0	1	0	2	3 (10.7%)
Loss of appetite	0	1	0	0	1 (3.6%)
Constipation	0	0	0	1	1 (3.6%)
Diarrhea	0	1	0	9†	10 (35.7%)
Neutropenia	0	1	1	2	4 (14.3%)
Thrombocytopenia	0	1	1	0	2 (7.1%)
Interstitial lung disease	0	0	0	1†	1 (3.6%)

^† One of the adverse effect was grade 3 in each group, respectively.