TABLE 5.
ORs and 95% CIs for symptomatic progression of knee osteoarthritis according to quartiles of dietary pattern scores1
| Model 12, 4 | Model 23, 4 | |||||||
|---|---|---|---|---|---|---|---|---|
| Cases | Person-years | OR (95% CI) | P-value | P-trend | OR (95% CI) | P-value | P-trend | |
| Western5 | ||||||||
| Q1 | 594 | 1156 | 1.00 | Ref | <0.01 | 1.00 | Ref | <0.01 |
| Q2 | 609 | 1130 | 1.08 (0.92, 1.27) | 0.32 | 1.06 (0.89, 1.25) | 0.51 | ||
| Q3 | 608 | 1105 | 1.20 (1.02, 1.41) | 0.03 | 1.15 (0.97, 1.37) | 0.11 | ||
| Q4 | 629 | 1071 | 1.39 (1.18, 1.63) | <0.01 | 1.26 (1.06, 1.50) | <0.01 | ||
| Prudent5 | ||||||||
| Q1 | 618 | 1077 | 1.00 | Ref | <0.01 | 1.00 | Ref | <0.01 |
| Q2 | 611 | 1094 | 0.90 (0.77, 1.06) | 0.20 | 0.90 (0.76, 1.07) | 0.22 | ||
| Q3 | 614 | 1141 | 0.92 (0.78, 1.07) | 0.27 | 0.90 (0.76, 1.06) | 0.21 | ||
| Q4 | 597 | 1150 | 0.73 (0.62, 0.86) | <0.01 | 0.71 (0.60, 0.84) | <0.01 | ||
| Western − prudent5 | ||||||||
| Q1 | 591 | 1128 | 1.00 | Ref | <0.01 | 1.00 | Ref | <0.01 |
| Q2 | 617 | 1176 | 1.19 (1.01, 1.39) | 0.03 | 1.19 (1.01, 1.41) | 0.04 | ||
| Q3 | 613 | 1114 | 1.24 (1.06, 1.46) | <0.01 | 1.22 (1.03, 1.44) | 0.02 | ||
| Q4 | 619 | 1044 | 1.40 (1.19, 1.64) | <0.01 | 1.29 (1.08, 1.53) | <0.01 | ||
COX-2, cyclooxygenase-2; JSW, joint space width; KL, Kellgren–Lawrence; MSM, methylsulfonylmethane; NSAID, nonsteroidal anti-inflammatory drug; PASE, Physical Activity Scale for the Elderly.
Adjusted for age, sex, race (African American, white, other), baseline KL grade 1–3, injury/surgery (yes, no), depression (yes, no), narcotics for pain (yes, no), NSAID use (yes, no), SAMe (yes, no), MSM (yes, no), doxycycline (e.g., Vibra-Tabs, Doryx, Adoxa) (yes, no), COX-2 inhibitors (Bextra, Celebrex) (yes, no), and baseline PASE score and total energy intake (kcal/day, continuous) using a generalized linear mixed model.
Additionally adjusted for BMI (<25.0, 25.0–29.9, and ≥30 kg/m2), and weight change from baseline (continuous)
Additional adjustment for income, education, smoking, and alcohol did not significantly alter results.
Western pattern: Q1 is more healthy, Q4 is less healthy; Prudent pattern: Q1 is less healthy, Q4 is more healthy; Western − prudent pattern: Q1 is more healthy, Q4 is less healthy.