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. 2019 Jul 7;10(3):475–487. doi: 10.1016/j.apsb.2019.07.001

Figure 6.

Figure 6

Correlation between TLR4-and RIG-I-mediated NF-κB signaling pathway in the brain and microbiota–gut–brain axis imbalance. The red oval node represents the TLR4-and RIG-I-mediated NF-κB signaling pathway in the brain, and the blue rectangular node represents gut microbiota. The orange rectangular node represents the intestinal barrier, and the purple rectangular node represents the cognitive function. The red edge represents the positive correlation, the black edge represents the negative correlation, and the gray dotted edge represents no correlation. The r represents Spearman's correlation coefficient. Data were collected from vehicle-treated and probiotic-treated SAMP8 mice (n = 5–6/group). One-tailed Spearman's analysis, confidence interval 95%.