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. 2019 Oct 18;10(3):488–497. doi: 10.1016/j.apsb.2019.10.004

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© 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Scheme 1 — Synthetic route of compound CHMFL-VEGFR2-002. Reagents and conditions: (a) hydrazine hydrate, t-BuOH, 115 °C, 5 h; (b) 2-mercapto-N-methylbenzamide, Pd₂(dba)₃, xantphos, Na₂CO₃, DMF, 80 °C, 14 h; (c) acetyl chloride, DMF, DIPEA, 0 °C–r.t., 8 h; (d) 1,2-DAP, THF, 60 °C, 6 h.