Table 1.
Anti-proliferation activity of CHMFL-VEGFR2-002 in BaF3 cell lines.
| Cell line | GI50 (nmol/L) |
Cell line | GI50 (nmol/L) |
||
|---|---|---|---|---|---|
| CHMFL-VEGFR2-002 | Sunitinib | CHMFL-VEGFR2-002 | Sunitinib | ||
| BaF3 | >10,000 | 2560 | TEL-FLT3-BaF3 | >10,000 | 32 |
| TEL-VEGFR2-BaF3 | 150 | 5 | TEL-BMX-BaF3 | >10,000 | 3020 |
| TEL-PDGFRa-BaF3 | 620 | 1 | BCR-DDR2-BaF3 | >10,000 | NA |
| TEL-PDGFRb-BaF3 | 618 | <1 | TEL-EPHA1-BaF3 | >10,000 | 3210 |
| TEL-VEGFR1-BaF3 | 9900 | 350 | TEL-EPHA2-BaF3 | >10,000 | 1270 |
| TEL-VEGFR3-BaF3 | >10,000 | 570 | TEL-CSF1R-BaF3 | >10,000 | 11 |
| TEL-cKIT-BaF3 | >10,000 | 81 | TEL-FGFR1-BaF3 | >10,000 | 1680 |
| TEL-RET-BaF3 | >10,000 | 110 | TEL-FGFR2-BaF3 | >10,000 | 4 |
| TEL-ABL-BaF3 | >10,000 | 1550 | TEL-FGFR3-BaF3 | >10,000 | 370 |
| P210-BaF3 | >10,000 | 1460 | TEL-FGFR4-BaF3 | >10,000 | 2820 |