Fig. 4. Pooled effects of PH-specific agents versus controls on changes in clinical parameters and for incidence of serious adverse events; (A) St. George's Respiratory Questionnaire score, (B) Borg dyspnea score after walk test, (C) 6-minute walk distance, and (D) incidence of serious adverse events. A serious adverse event was defined as an event that resulted in death, was life-threatening, resulted in hospitalization or prolongation of hospitalization, resulted in persistent or clinically significant disability or incapacity, was a congenital anomaly or birth defect, or was deemed to be serious for any other reason.

PH = pulmonary hypertension, MD = mean difference, SD = standard deviation, CI = confidence interval.