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Proposed mechanisms involved in the anti-fibrotic activity of embelin. The anti-fibrotic activity of embelin is thus far reported in PC model, where it can inhibit PSC survival in a dose-dependent manner. Embelin down-regulated the SHH signaling pathway and consequently, the expression of fibrogenic mediators, such as α-SMA, fibronectin, type I collagen is decreased. This suggests that embelin able to alleviate the development of fibrosis.
