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. 2020 Jan 16;4(3):434–449. doi: 10.1002/hep4.1474

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© 2020 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Animal weight and glucose determination. (A) Weekly weight gain. Switch diet and SDP groups changed diet at week 8, with dramatically diminishing weight. (B) Weight at sacrifice. (C) Epididymal adipose fat pad weight. The HFP group showed a statistical diminution in animal and fat weight compared with the HF animals (P < 0.01). (D) Fasting glucose at week 16. HFP animals presented a slight decrease in serum glucose compared with the HF group. (E) ITT. The HFP group showed insulin sensitivity comparable to the ND group. (F) The AUC for ITT is improved in HFP animals (P < 0.01). Data are expressed as the media of the group ± SEM. Abbreviations: ns, not significant; SD, switch diet.