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. 2020 Jan 3;4(3):371–386. doi: 10.1002/hep4.1471

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© 2020 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Squirrel monkey liver chimeric FNRG mice support WMHBV infection and transcription. FNRG mice were engrafted with either primary human or squirrel monkey hepatocytes and were subsequently challenged with HBV or WMHBV. Primary hepatocyte engraftment was determined by ELISA for circulating albumin of the respective species. (A) Albumin levels for FNRG mice engrafted with primary human hepatocytes. (B) Albumin levels for FNRG mice engrafted with squirrel monkey hepatocytes. The red arrow depicts when mice were challenged with either HBV or WMHBV. The dotted line indicates the limit of detection for the assay. Quantification of total HBV and WMHBV DNA (C) and pgRNA (D) in liver tissues from human and squirrel monkey liver chimeric mice that had been challenged with either HBV or WMHBV. Abbreviation: Alb, albumin.