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. 2020 Jan 25;48(5):2271–2286. doi: 10.1093/nar/gkaa028

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — The NA_H/ACA snoRNA are part Alu repeat elements. (A) The position of NA_H/ACA snoRNA cluster_25 (magenta box) is shown relative to the exons of its host gene (gray boxes) and the intronic AluSz6 element (blue box). (B) cluster_25 adopts the structure of an H/ACA snoRNA. The structure was predicted by both Turbofold (35) and snoGPS (33) showing the position of the H and ACA boxes. The snoRNA target-binding sites are circled. (C) The predicted modification target of cluster_25 in the 18S rRNA was determined using snoGPS and the pairing between the snoRNA and target indicated by the black lines. (D) Depletion of the H/ACA snoRNA binding protein dyskerin inhibits the expression of cluster_25. The average RNA abundance in TPM was determined in sequencing datasets of lipofectamine controls and cells transfected with two independent siRNAs targeting DKC1 (s1 and s2).