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. 2020 Jan 24;48(5):2232–2245. doi: 10.1093/nar/gkaa036

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — CAA Interrupts near the loop can stabilize (CAG)₁₅ strand-slipping transitions. (A) Schematics of possible folding configurations and smFRET results for (CAG)₁₅ and several CAA interrupted (CAG)₁₅ TR hairpins. Sequences are indicated at the top of the diagram. Slip designation and observed populations are indicated along the lower edge. Results of (CAG)₁₅ experiment from Figure 2 are listed for comparison. (B–D) Histograms of smFRET measurements for the hairpins diagramed in (A). (E) Representative time traces (upper panels, donor signal in blue, acceptor signal in red) and calculated FRET values (lower panels, black) for the (CAG)₁₅ and the CAA interrupted (CAG)₁₅ TR hairpins.