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. 2020 Feb 26;13:535–544. doi: 10.2147/DMSO.S235869

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© 2020 Li et al.

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PRMT4 overexpression promotes lipolysis in mice.

Notes: (A–D) Lipolysis was tested in mice with streptozotocin (STZ)-induced diabetes and in control mice. The gross morphology of the fat pads (A) and the tissue weights (B) of the inguinal white adipose tissue (iWAT) and epididymal white adipose tissue (eWAT) were recorded. Representative images of H&E-stained sections of eWAT (C), and frequency distribution of the adipocyte sizes of eWAT (D). (E and F) Weights of the iWAT and eWAT (E) and levels of serum-free fatty acids (FFAs) (F) determined in adeno-associated virus (AAV) control-infected fed mice (Ctrl-Fed), AAV-control-infected fasted mice (Ctrl-Fasted), and AAV-PRMT4-infected fasted mice (PRMT4-Fasted). *P < 0.05 indicates a significant difference between the Ctrl-STZ and Ctrl-vehicle groups or the Ctrl-Fasted and Ctrl-Fed groups. ^#P < 0.05 indicates a significant difference between the PRMT4-STZ and Ctrl-STZ groups or the PRMT4-Fasted and Ctrl-Fasted groups.