Table 1. Characteristics and incidence of post-extraction MRONJ according to BP discontinuation (n=465 patients).
| Variable | Group | P-value | |
|---|---|---|---|
| BPC | BPDC | ||
| All patients | (n=179) | (n=286) | |
| Sex (female:male) | 159:20 | 261:25 | 0.422 |
| Age (yr) | 70.3±9.2 | 67.8±8.9 | 0.003* |
| Duration of BP administration (mo) | 40.0±35.6 | 14.0±16.8 | <0.001* |
| Duration of IV BP administration (mo) | 23.0±18.7 | 13.4±18.6 | 0.171 |
| Duration of BP discontinuation (mo) | 0 | 39.0±35.5 | <0.001* |
| PO:PO+IV:IV | 149:15:15 | 260:15:11 | 0.040* |
| Surgical extraction with osteotomy | 40 | 61 | 0.818 |
| Osteoporosis:cancer | 175:3 | 283:3 | 0.680 |
| Post-extraction MRONJ | 1 | 0 | 0.385 |
| BP administration for more than 3 yr | (n=89) | (n=33) | |
| Sex (female:male) | 85:4 | 32:1 | 0.999 |
| Age (yr) | 69.6±9.1 | 69.7±9.4 | 0.924 |
| Duration of BP administration (mo) | 65.2±34.6 | 53.3±12.2 | 0.057 |
| Duration of BP discontinuation (mo) | 0 | 28.1±30.6 | <0.001* |
| PO:PO+IV:IV | 77:5:7 | 28:2:3 | 0.970 |
| Surgical extraction with osteotomy | 23 | 10 | 0.650 |
| Osteoporosis:cancer | 89:0 | 30:3 | 0.018* |
| Post-extraction MRONJ | 1 | 0 | 0.999 |
(MRONJ: medication-related osteonecrosis of the jaw, BP: bisphosphonate, BPC: BP-continuation, BPDC: BP-discontinuation, IV: intravenous, PO: oral administration)
*P<0.05.
Values are presented as number of patients only or mean±standard deviation.